Non-Ossifying Fibromas

Non-Ossifying Fibromas (NOFs) are benign bone lesions frequently present in the immature skeleton (children).


The lesion are the result of an error of ossification (the process by which the cartilaginous growth plate transforms into the growing bone). When this occurs fibrous tissue, instead of bone, is produced. NOFs are common incidental findings on radiographs as they are usually asymptomatic. If large enough though, NOFs can affect the structural integrity of the bone and result in a fracture. Otherwise, they spontaneously reabsorb which is why they are not found in the bones of skeletally mature adults.

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